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HomeNewsTrendsHealthModerna discusses COVID-19 vaccine manufacturing with Nexus Pharmaceuticals: Report

Moderna discusses COVID-19 vaccine manufacturing with Nexus Pharmaceuticals: Report

Senior White House and administration officials, including David Kessler, chief science officer for Covid response and Tim Manning, COVID-19 supply coordinator, have facilitated introductions and discussions between Nexus, Moderna and Johnson & Johnson, according to two sources.

April 15, 2021 / 11:35 IST
Source: Reuters

Moderna Inc, looking to boost production of its COVID-19 vaccine, met with Nexus Pharmaceuticals to discuss manufacturing the shot at the company’s new plant in Wisconsin, which has the capacity to process and fill 30 million doses a month, sources with knowledge of the matter said.
The meeting between Moderna and the maker of specialty drugs took place on Tuesday, the sources said.

Senior White House and administration officials, including David Kessler, chief science officer for Covid response and Tim Manning, COVID-19 supply coordinator, have facilitated introductions and discussions between Nexus, Moderna and Johnson & Johnson, according to two sources.

Follow our LIVE blog for latest updates of the novel coronavirus pandemic
Even though President Joe Biden has said there would be enough vaccines for all adults in the United States by May, there could still be supply concerns later in the year, particularly if people require a booster shot at some point to protect against concerning virus variants that may be circulating.

It remains unclear if the meeting will result in a deal to manufacture vaccines at the Nexus plant, the sources said. Funding from the Defense Production Act will be essential for a deal to work, one of the sources said.

“Moderna is looking to produce more vaccines ... and Nexus has the capacity to do it,” one of the sources said.

COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Illinois-based Nexus does not currently manufacture COVID-19 vaccines but has built capacity to ramp up production at their new plant in Wisconsin, one of the sources said.

The White House declined comment on the meeting. Nexus and Moderna also declined comment.

On Tuesday, Moderna said it was on track to deliver 300 million doses to the United States by the end of July, in line with its commitments. Moderna delivered 45 million vaccines to US states in March.

Moderna’s chief executive on Wednesday said the company was unlikely to markedly speed up its vaccine production in the next few months, though it expects the output to have increased significantly by 2022.

The Biden administration has previously brokered commitments among rival drugmakers to boost COVID-19 vaccine production.

In March, Biden announced that Merck & Co will help manufacture Johnson & Johnson’s single-shot coronavirus vaccine.

Despite its efforts there have been significant setbacks.

For example, some 15 million doses of J&J’s vaccine were wasted due to contamination with ingredients from AstraZeneca’s shot at a Baltimore plant that was producing both. That Emergent BioSolutions facility will now produce only the J&J shot.

Separately, US federal health agencies on Tuesday recommended pausing use of the J&J COVID-19 vaccine while it looks into six cases of rare brain blood clots in women under age 50 who received the shot.

Follow our full coverage of the coronavirus pandemic here.

Reuters
first published: Apr 15, 2021 11:20 am

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