Children today may be growing up faster than ever, and not just metaphorically. A recent Taiwanese study has drawn links between widely used sweeteners, such as aspartame, sucralose, and glycyrrhizin, and early puberty, especially in youngsters with specific genetic profiles. These substances appear to disrupt hormonal signals and even alter gut bacteria, with different effects observed in boys and girls.
Early puberty isn’t just about taller kids sooner, it can come with emotional turbulence and long-term health concerns, too. Presented at ENDO 2025 (the Endocrine Society’s annual meeting), the study tracked 1,407 children through the Taiwan Pubertal Longitudinal Study. Of these, 481 showed signs of early puberty.
The researchers analysed their sweetener intake, via food logs and urine samples, as well as their genes. Children who consumed more sweeteners were significantly more likely to enter puberty early, particularly if they carried certain genetic markers.
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Previous work from the same team showed that AceK, a commonly used sweetener, can trigger puberty-related hormones and raise stress-linked brain chemicals. Glycyrrhizin, found naturally in liquorice, was shown to alter gut bacteria and genes tied to puberty timing.
Gender differences were striking, too
While boys were more susceptible to sucralose, girls were affected by a broader range of sweeteners, including glycyrrhizin and added sugars. These findings suggest that ordinary dietary choices could play a bigger role in childhood development than we ever suspected.
What parents need to know
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