A tiny mouse with mammoth-like traits may seem unusual. But for scientists, it is a step toward bringing back the woolly mammoth. Colossal Biosciences, a US-based company, has announced the successful creation of the Colossal Woolly Mouse, a genetically engineered mouse with features adapted for cold climates.
Mammoth Traits in a Mouse
Colossal Biosciences revealed that its researchers modified seven genes in mice. These genes are linked to thick fur, coat texture, and other adaptations seen in woolly mammoths. The company said the experiment confirms that key mammoth traits can be recreated in living animals.
The genetic changes were based on data from 59 mammoth genomes, some dating back 1.2 million years. Scientists also analysed a set of 121 elephant and mammoth genomes, including reference genomes for Asian and African elephants. They identified 10 genes responsible for hair length, colour, and fat metabolism, selecting seven for the experiment.
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A Step Towards De-Extinction
Ben Lamm, co-founder and CEO of Colossal Biosciences, called the project a major moment in their mission. He stated that the success proves scientists can recreate complex genetic traits that evolved over millions of years.
Dr Beth Shapiro, the company's chief science officer, highlighted the significance of this research. She said the woolly mouse validates their approach to restoring extinct traits through genome editing.
A Living Model for Cold Adaptation
This experiment marks the first time an animal has been engineered with multiple cold-adapted mammoth traits. It also provides a living model to study how mammals adapt to freezing environments.
Lamm added that the research shows the entire process of gene selection, editing, and animal development is possible. The company believes this success brings them closer to reintroducing the woolly mammoth to the Arctic tundra.
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