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HomeNewscoronavirusCOVID-19 update | Moderna CEO advocates third vaccine dose to protect people at risk

COVID-19 update | Moderna CEO advocates third vaccine dose to protect people at risk

The CEO of the US drugmaker suggests that in order to protect the "fragile unvaccinated people," all adults and adolescents must receive a booster jab.

May 23, 2021 / 17:58 IST
Moderna CEO Stephane Bancel (Pic Credits: CNBC)

Amid global concerns over the possibility of variant viruses breaking through the vaccine's protection, US-based pharmaceutical major Moderna's CEO Stephane Bancel on May 23 said vaccination with a booster shot is a good way to protect those at risk against ever-emerging new COVID-19 variants.

"We believe that our vaccine will be effective for a comparable period, except that the arrival of variants increases the threat level. This is why we must anticipate and vaccinate all people at risk with a third dose by the end of the summer, in particular the residents of nursing homes who received their first dose at the beginning of the year," Bancel told French newspaper Journal Du Dimanche, reported news agency ANI.

The CEO of the US drugmaker further suggested that in order to protect the "fragile unvaccinated people," all adults and adolescents must also receive a booster jab.

In March this year, the National Institutes of Health began testing a variety of offerings from Moderna to use as a third shot designed to boost immunity protection as concern grows about emerging variants — including the one first discovered in South Africa, also known as the B.1.351 variant, reported CNBC.

Bancel warned that three or even two months of delay in vaccinations could lead to an increase in the number of hospitalisations and deaths, which could, in turn, lead to a fourth COVID-19 wave in France.

COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Moderna is now testing three different booster strategies, he said. The first is against the original Wuhan strain, the second is against the South Africa strain and the third is a combination of both. The effectiveness of these three boosters is later on measured on the four variants deemed to be the most dangerous by the World Health Organization.

The company is planning to launch a study on people near early June and aims to get approval from regulatory agencies by September.

Starting May 28, the Moderna vaccine will be joining AstraZeneca and Johnson & Johnson in French pharmacies and general practitioners' offices. Around 300,000 doses of the vaccine will be available in pharmacies weekly. The arrival of Moderna in French pharmacies is expected to make the vaccine more accessible to isolated elderly people or overlooked workers and will help with speedier vaccination progress in the country as the vaccine itself can be stored in the refrigerator for up to one month.

Studies have shown that the Moderna vaccine is more than 90 percent effective six months after the second dose, but it is unclear how long it provides protection.

So far, about 90 million people have been inoculated with Moderna's COVID-19 vaccine globally. Around 14 percent of France's total population has been fully vaccinated and 31.5 million people have received at least one dose.
With inputs from ANI

Moneycontrol News
first published: May 23, 2021 05:53 pm

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