Oxford’s COVID- 19 vaccine shown to start providing immunity in 14 days

2 | Next crop of COVID-19 vaccine developers take more traditional route: The handful of drugmakers dominating the global coronavirus vaccine race are pushing the boundaries of vaccine technology. The next crop under development feature more conventional, proven designs. The world will need several different vaccines to fight the COVID-19 pandemic, given the sheer size of global need, variations in effects on different populations, and possible limits of effectiveness in the first crop. Many leading candidates now in final-stage testing are based on new, largely unproven technology platforms designed to produce vaccines at speed.

A vaccine candidate developed by the University of Oxford against the novel coronavirus appears safe and induces a strong immune response within the body, scientists announced on July 20. This came after phase-I of "promising" human trials against COVID-19, the disease caused by the SARS-Cov2 virus.

Globally, there have been over 1.46 crore confirmed cases of COVID-19. More than 6.06 lakh people have died so far.

Details of the trail

Doses of the vaccine were given to 1,077 healthy adults aged between 18 and 55 in five United Kingdom hospitals in April and May as part of the phase-I clinical trial and results, published in the ‘Lancet' medical journal.

The vaccine candidate, called ChAdOx1 nCoV-19, showed a significant increase in T-cell responses targeting SARS-CoV-2 spike protein in 43 of the participants. The response peaked after 14 days, as per the journal.

The results show they induced strong antibody and T-cell immune responses for up to 56 days after they were given. T-cells are crucial for maintaining protection against the virus for years.

The findings are seen as promising, but experts feel it is too soon to know if this is enough to offer protection as larger trials get underway.

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Trails in India

The Serum Institute of India (SII) said it will apply for licence from the Indian regulator to start clinical trials of the Oxford University candidate in a week's time.

SII, the largest vaccine manufacturer in the world, has been chosen by Oxford and its partner AstraZeneca to manufacture the vaccine once it gets ready.

Earlier, Pune-based SII had said that it will start manufacturing the vaccine even before the final nod so as to be ready with sizeable volumes once the vaccine gets all permissions.

(With inputs from PTI)

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