Russian sovereign fund RDIF on June 17 said its COVID-19 vaccine Sputnik V will soon offer a booster shot, adjusted to work against the Delta variant of coronavirus, to other vaccine manufacturers.
Sputnik V uses heterogeneous boosting with two shots by two different adenoviral vectors Ad5 and Ad26. The adenoviral vector Ad26 is used for prime-boost, and Ad5 is used as a booster dose. RDIF didn't clarify whether it would be adjusting the Ad5 vector against the Delta variant.
RDIF also announced that it will be launching a single dose Sputnik Light vaccine which will be based on the Ad26 vector in India.
B.1.617.2 or Delta variant first detected in India, has now emerged as a variant of concern globally - potentially reducing the effectiveness of vaccines.
RDIF was the first to propose the mixing of the Sputnik V vaccine with the AstraZeneca (Covishield) vaccine to increase effectiveness. The joint clinical trial of the cocktail vaccine is currently underway.
Many companies like Pfizer, AstraZeneca, Johnson & Johnson, Novavax, among others are looking at mixing their vaccines with others or use them as boosters. But this needs clinical validation on safety, immunogenicity and efficacy.
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