Darren Eales stepped down for health reasons after announcing last September that he had been diagnosed with a chronic form of blood cancer.
It was a sickening blow for Newcastle who were again without outcast striker Isak, but who began the game in superb fashion.
The 25-year-old striker said he informed Newcastle of his desire to leave a long time ago.
Newcastle suffered heartbreak two years ago in the League Cup final against Manchester United, but they were determined to write their names into folklore as they tapped into the energy from their supporters.
The University of Oxford’s newest graduate college is named after them (Reuben College).
The visitors were gifted the opening goal in the fifth minute as Cancelo acrobatically crossed for Ruben Dias to head into an empty net after a mix-up between goalkeeper Martin Dubravka and defender Ciaran Clarke.
The investigation is the latest scrutiny of Singaporean business duo Terence and Nelson Loh since Reuters reported their other firm behind the Newcastle United bid doctored photos of Barack Obama and made other suspect claims in marketing materials.
British billionaire Mike Ashley, who made his fortune from sportswear retailer Sports Direct (renamed Frasers Group last month) has owned Newcastle United since 2007.
Depression affects large numbers of footballers in the English professional game according to a survey by soccer magazine Four Four Two.