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HomeNewscoronavirusJoe Biden’s COVID-19 vaccine shift has risky side effects

Joe Biden’s COVID-19 vaccine shift has risky side effects

May 06, 2021 / 18:43 IST
US President Joe Biden (File image: AP Photo)

Joe Biden’s vaccine revolution risks creating lingering ailments. The U.S. president’s decision to back removing intellectual property protections on Covid-19 jabs is a logical move, but practical difficulties mean it may not do much to help pandemic-ravaged countries. The danger is Big Pharma is less keen to develop new treatments in the next crisis.

The U.S. government had resisted a World Trade Organization proposal to force drug companies to share their vaccine patents during the pandemic. Biden’s move comes amid a dramatic increase in Covid-19 deaths in India and Brazil, two countries that have trailed their Western peers when it comes to vaccine access. His backing gives the proposals a realistic shot: European Commission President Ursula von der Leyen promptly said Europe is willing to discuss it.

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In theory, removing patent protection makes sense. It would reduce the cost of making vaccines for poorer countries, and make it easier for them to develop a broader range of remedies. Citizens in richer countries would also gain, as fewer infections would also limit the emergence of dangerous mutations.

Practical challenges, however, mean it is unlikely to make a big difference. The largest obstacle to widespread vaccines takeup is not the existence of patents, but the shortage of raw materials and manufacturing capacity. Drug companies like AstraZeneca have scoured the globe to arrange partnerships with companies such as the Serum Institute of India and Siam Bioscience in Thailand. GlaxoSmithKline and Sanofi , which do not have approved treatments, are helping manufacture other group’s drugs. Complex vaccines, such as Pfizer and Moderna’s mRNA remedy, require costly cold storage, making it difficult for unspecialised manufacturers to replicate.

COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Still, the move has rattled drug companies’ shares, with Moderna and Novavax’s stocks falling as much as 13% on Wednesday. One concern is that the emergency temporary intervention opens the door to similar moves, say on insulin or cancer drugs. That looks unlikely: it may be hard to marshal international support for such a move outside of a crisis. But the bigger concern is that during the next pandemic companies are less keen to develop new drugs, and charge higher prices initially to recoup their costs. That would be an unwelcome side effect for a relatively weak treatment.
Reuters
first published: May 6, 2021 06:43 pm

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