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High blood sugar levels can affect exercise benefits, here's how keto diet can help

A new study suggests that high blood sugar may block some key benefits of exercise. However, researchers discovered that a high-fat ketogenic diet helped restore those benefits in mice by normalising blood sugar and improving how muscles use oxygen. Here’s what the study reveals

March 10, 2026 / 14:39 IST
High blood sugar can limit the benefits of exercise. Researchers find that diets like ketogenic or Mediterranean may enhance muscle endurance and aerobic efficiency by supporting healthy blood sugar levels. (Photos: Pexels)
Snapshot AI
  • High blood sugar limits exercise benefits and muscle adaptation
  • Ketogenic diet in mice improved blood sugar and muscle endurance
  • Balanced diets enhance exercise benefits and metabolic health.

Do you ever think why some workouts feel powerful while others leave little impact? Scientists now believe the answer may partly lie in the diet you follow.

Exercise is widely seen as one of the most reliable ways to stay healthy. It strengthens the heart, builds muscle and helps the body produce energy more efficiently. One of the most important signs of good fitness is how well the body uses oxygen during activity. When this process improves, it often signals stronger endurance and better long-term health.

However, people with high blood sugar may not receive these full benefits. Increased glucose levels can interfere with the body’s ability to increase oxygen uptake during exercise. This means that even when someone exercises regularly, their muscles may struggle to adapt in the way they should.

Researchers at Virginia Tech explored what if increasing fat intake could help restore the body’s response to exercise? Their study examined mice fed a ketogenic diet, a high-fat and very low-carbohydrate eating plan designed to shift the body into a metabolic state known as ketosis.

Also Read: Exercise is not just about building muscles or burning calories, it could be a cultural experience too

In ketosis, the body stops relying mainly on sugar for fuel and begins burning fat instead. Within just a week, the mice experienced a dramatic drop in blood sugar. Their glucose levels returned to normal, almost as if diabetes had disappeared.

But the most striking change appeared in their muscles.

Here’s how muscles transformed

Slowly, the mice began to show stronger responses to exercise. Their muscles developed more slow-twitch fibres, the type associated with endurance and long-distance activity. These fibres allow muscles to sustain activity for longer periods while using oxygen more efficiently. Which means, their bodies became better at aerobic exercise.

Additionally, researchers also observed that the muscles became more “oxidative”, meaning they were more efficient at producing energy through oxygen use, a major indicator of cardiovascular fitness.

Uncover why diet and exercise work together

The findings highlight that diet and exercise are deeply connected. Exercise affects nearly every tissue in the body, including fat tissue. But its full benefits may depend on what people eat. When diet supports healthy blood sugar levels, the body appears to adapt to exercise more effectively. When sugar levels remain high, those adaptations may be limited.

Although the research was conducted in mice, the results open the door to new ways of improving metabolic health. The ketogenic diet has long been used to treat conditions such as epilepsy and was historically used to manage diabetes before insulin became available. Nevertheless, it can be difficult for many people to maintain because it requires strict carbohydrate limits.

Also Read: From keto to paleo: Why simple, balanced eating works best

For this reason, researchers suggest that other balanced diets, such as the Mediterranean diet, which includes whole grains, fruits and vegetables, may also help support healthy blood sugar while allowing people to gain more from exercise.

The next step is to test whether the same effects occur in humans. If confirmed, the discovery could change how doctors and scientists think about fitness, particularly for people with high blood sugar. Instead of focusing only on exercise or diet alone, the real secret to better health may lie in how the two work together.

FAQs on Hidden Exercise Benefits of the Keto Diet

1. How does the keto diet enhance exercise benefits?

The keto diet helps lower blood sugar levels and improves the body’s ability to use oxygen during exercise, enhancing endurance and cardiovascular fitness.

2. Can the keto diet benefit everyone?

While it has notable benefits, the keto diet is strict and may be difficult to maintain. Other balanced diets, like the Mediterranean diet, might also support exercise benefits.

3. Is the keto diet effective for humans as well?

The current findings are based on animal studies. Further research is needed to confirm if the same benefits apply to humans.

Disclaimer: This article, including health and fitness advice, only provides generic information. Don’t treat it as a substitute for qualified medical opinion. Always consult a specialist for specific health diagnosis

Namita S Kalla is a senior journalist who writes about different aspects of modern life that include lifestyle, health, fashion, beauty, and entertainment.
first published: Mar 10, 2026 02:39 pm

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