Hyderabad-based pharmaceutical firm Bharat Biotech in collaboration with the Indian Council of Medical Research - National Institute of Virology developed an inactivated virus-based COVID-19 vaccine and named it Covaxin. This has been code-named as BBV152. According to CoWin statistics, till October 2021, around 110.6 million people in India have received Covaxin. Also, the World Health Organisation on November 3, 2021, validated the vaccine for emergency use and Covaxin has been granted emergency use approval in 13 countries as of January 31, 2022. Speaking about the efficacy of Covaxin, the vaccine has been proved to be 64 percent effective against asymptomatic cases, 78 percent effective against symptomatic disease, 93 percent effective against severe disease, and 65 percent effective against the Delta variant. India's Central Drugs Standard Control Organization (CDSCO) recommended permission for Covaxin on January 2, 2021, which was granted the next day. The government approved Bharat Biotech's Covaxin for usage on children between 2 and 18 years of age on October 12, 2021. Apart from India, the vaccine was also approved for emergency use in Iran, Zimbabwe, Nepal, Mexico, Philippines, Guatemala, Nicaragua, Guyana, Venezuela and Botswana. In terms of foreign shipment, Mauritius received its first commercial supply of Covaxin on March 18, 2021. Similarly, Paraguay received 100,000 doses of Covaxin on March 29, 2021 and Argentina agreed to buy 10 million doses of Covaxin and administer them to its citizens in June 2021. More
The vaccine, sold under brand name Covaxin, showed an immune response in individuals who had not received a COVID vaccine previously as well as those vaccinated with mRNA vaccines by Pfizer Inc and Moderna Inc, meeting its main goals, Ocugen said.
Covaxin was found to be well-tolerated in vaccine-naïve individuals and in individuals previously vaccinated with mRNA vaccines in the US with no vaccine-related serious adverse events, Bharat Biotech’s partner in the country has announced
Vaccination following exposure to the Delta or Omicron variants of SARS-CoV-2 is likely to affect the quality, quantity and duration of immune responses.
There have been media reports claiming that Bharat Biotech, manufacturer of the indigenous COVID-19 vaccine Covaxin, had to skip certain processes and 'speed' up clinical trials due to political pressure, the ministry said.
As the infection rate has been sturdily declining globally, exports of Covaxin were negatively impacted with poor off take by foreign countries.
With Bharat Biotech completing clinical trials of its vaccine candidate, hopes have been raised about the availability of intranasal vaccine as a booster dose just as the number of daily Covid-19 cases and test positivity rate in parts of India have started surging over the last few weeks.
This is for the first time that a booster dose that is different from the one used for primary vaccination against Covid has been allowed in the country.
The findings of the study have been published in the high-impact scientific journal Nature.
On July 17, India administered its 2 billionth COVID-19 vaccine dose, 18 months after the mammoth vaccination drive against coronavirus was launched. Of the total doses administered, 51 percent doses were given to women and 71 percent vaccination centres were in rural areas
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Biological E’s Corbevax has been recommended for administration in 5 to 12 years old children, while the Bharat Biotech’s Covaxin has been recommended for children in 6-12 years’ age group.
This is a remarkable feat, considering that all the vaccine doses administered in the country are made locally
In a phase II/III research, Bharat Biotech International Ltd's COVID-19 vaccine Covaxin was found to be safe, well-tolerated, and highly immunogenic in children and adolescents aged 2 to 18 years.
The company said that no adverse events of special interest have been reported to date. However, a supplementary surveillance study is going on, which will provide more information on rarer adverse events
Bharat Biotech, the manufacturer of Covaxin, announced on Thursday that his business can now forecast a pandemic based on changes in viral and related signals.
The protective efficacy of Bharat Biotech's Covaxin following two and three-dose immuniszations against the Delta variant and the efficacy of the Covaxin against Omicron variants were studied in a Syrian hamster model (animal model to study human-associated diseases), it said.
Bharat Biotech did not immediately react to the development, but company sources reportedly said that all export orders already stand cancelled as the production has been halted.
The pharma regulator has approved the first mix-and-match of COVID-19 vaccines in India, but the final say-so lies with the government
German Ambassador to India and Bhutan, Walter J Lindner on Thursday said the government of the European nation will start recognizing Bharat Biotech’s COVID-19 vaccine for travel purpose there from June 1.
The FDA’s earlier decision, in April, to put on hold the trials was based on the US firm’s decision to voluntarily implement a temporary pause in dosing participants of the jab, following the World Health Organisation’s observations on Covaxin manufacturing plants in India.
Covovax, the Covid-19 vaccine manufactured by the Serum Institute of India under licence from US firm Novavax, will be available at Rs 225 per dose, excluding taxes, at private healthcare facilities.
Presently, precaution dose of Covaxin and Covishield is administered to all those aged above 18 who have completed nine months after the second dose.
In a communication to Dr V K Paul, the convenor of a key empowered group on COVID vaccination, on Tuesday the Ministry of External Affairs said many issues about vaccines and international travel by Indians have arisen and these must be addressed immediately.
When asked if the gap for taking the booster dose has been reduced from nine months to six, the minister said, NTAGI is the panel to take decisions in this regard.
Government approval for the administration of COVID-19 vaccines to children in the 5-11-year age group is possible as early as next week, according to health ministry officials familiar with the situation.