After contracting the coronavirus in March, Michael Reagan lost all memory of his 12-day vacation in Paris, even though the trip was just a few weeks earlier.
Several weeks after Erica Taylor recovered from her COVID-19 symptoms of nausea and cough, she became confused and forgetful, failing to even recognize her own car, the only Toyota Prius in her apartment complex’s parking lot.
Lisa Mizelle, a veteran nurse practitioner at an urgent care clinic who contracted the virus in July, finds herself forgetting routine treatments and lab tests and has to ask colleagues about terminology she used to know automatically.
“I leave the room, and I can’t remember what the patient just said,” she said, adding that if she hadn’t exhausted her medical leave she’d take more time off.
“It scares me to think I’m working,” Mizelle, 53, said. “I feel like I have dementia.”
Frequently Asked Questions
A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.
There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.
Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.
It’s becoming known as COVID brain fog: troubling cognitive symptoms that can include memory loss, confusion, difficulty focusing, dizziness and grasping for everyday words. Increasingly, COVID survivors say brain fog is impairing their ability to work and function normally.
“There are thousands of people who have that,” said Dr. Igor Koralnik, chief of neuro-infectious disease at Northwestern Medicine in Chicago, who has already seen hundreds of survivors at a post-COVID clinic he leads. The impact on the workforce that is affected is going to be significant, he added.
Scientists aren’t sure what causes brain fog, which varies widely and affects even people who became only mildly physically ill from COVID-19 and had no previous medical conditions. Leading theories are that it arises when the body’s immune response to the virus doesn’t shut down or from inflammation in blood vessels leading to the brain.
Confusion, delirium and other types of altered mental function, called encephalopathy, have occurred during hospitalization for COVID-19 respiratory problems, and a study found such patients needed longer hospitalizations, had higher mortality rates and often couldn’t manage daily activities right after hospitalization.
But research on long-lasting brain fog is just beginning. A French report in August on 120 patients who had been hospitalized found that 34% had memory loss and 27% had concentration problems months later.
In a soon-to-be-published survey of 3,930 members of Survivor Corps, a group of people who have connected to discuss life after COVID-19, more than half reported difficulty concentrating or focusing, said Natalie Lambert, an associate research professor at Indiana University School of Medicine, who helped lead the study. It was the fourth most common symptom out of the 101 long-term and short-term physical, neurological and psychological conditions that survivors reported. Memory problems, dizziness or confusion were reported by one-third or more respondents.
“It is debilitating,” said Rick Sullivan, 60, of Brentwood, California, who has had episodes of brain fog since July after overcoming a several-week bout with COVID-19 breathing problems and body aches. “I become almost catatonic. It feels as though I am under anesthesia.”
Unable to Work
When Taylor, 31, contracted the virus in mid-June, she thought she’d need only a brief break from working as a lawyer for an Atlanta nonprofit helping low-income tenants.
But she became so disoriented that she washed her TV remote with her laundry and had to return a foster dog she’d recently taken in because she couldn’t trust herself to care for a pet.
One morning, “everything in my brain was white static,” she said. “I was sitting on the edge of the bed, crying and feeling, ‘Something’s wrong; I should be asking for help,’ but I couldn’t remember who or what I should be asking. I forgot who I was and where I was.”
By July, she thought she’d improved and told her boss she could return. But after another “white static” episode, she messaged him: “‘I’m scared. I really want to get back to work. But, I keep getting really tired and really confused.’” He suggested she rest and heal.
She resumed working in early August, but her mind wandered, and reading emails was “like reading Greek,” she said. By September, her employer urged a 13-week leave.
“They finally landed on, ‘You’re going to have to step away,’” said Taylor, who requested to volunteer for the nonprofit while on leave but was told no. “I’m gutted, to be honest.”
Reagan, 50, who spent five days in and out of hospitals, initially resumed work as a vascular specialist for a company that makes stents and catheters.
But finger tremors and seizures, neurological symptoms that sometimes accompany brain fog, meant “there is no way I’m going to go into surgery and teach a doctor how to suture an artery,” he said.
In meetings, “I can’t find words,” said Reagan, who has now taken a leave. “I feel like I sound like an idiot.”
Before Mizelle contracted the virus in July and was hospitalized with pneumonia for five days in August, she’d treat six patients an hour by herself at her clinic in Huntsville, Alabama. But recently, she said, “I told our scheduler I can’t work alone because I’m slow in thinking, I’m dizzy, and I just need somebody else there to work with me.”
Sometimes in exam rooms, she said, “I’m trying to be slick with the patient so they don’t know, because you don’t want your provider to be in a fog, which is very scary.”
Brain fog’s cause is a mystery partly because symptoms are so varied.
“The simplest answer is, people still have persistent immune activation after the initial infection subsided,” said Dr. Avindra Nath, chief of infections of the nervous system at the National Institute of Neurological Disorders and Stroke.
Inflammation in blood vessels, or cells lining the vessels, may be involved, said Dr. Serena Spudich, chief of neurological infections and global neurology at Yale School of Medicine. Inflammatory molecules, released in effective immune responses, “can also be sort of toxins, particularly to the brain,” she said.
Tiny strokes may cause some symptoms, said Dr. Dona Kim Murphey, a neurologist and neuroscientist, who herself has experienced post-COVID neurological issues, including “alien hand syndrome,” in which she felt a “superbizarre sense of my left hand, like I didn’t understand why it was positioned the way it was, and I was really captivated by it.”
Other possible causes are autoimmune reactions “when antibodies mistakenly attack nerve cells,” Spudich said.
Symptoms like tingling or numbness can occur when damaged nerves send wrong signals, said Dr. Allison Navis, a neuro-infectious disease specialist at Mount Sinai Health System. Some people with brain fog still experience lung or heart issues, which can exacerbate neurological symptoms.
So far, MRI scans haven’t indicated damaged brain areas, neurologists say.
Murphey, scientific director for a brain wave technology company, who couldn’t summon the word “work” in a recent meeting, said research is crucial so symptoms are taken seriously.“People say in a disparaging way, ‘It’s all in their head,’” she said. “In this case it is literally in our heads, and it is very real.”