Weight loss drug Ozempic: Stars who said they’ve used the prescription drug to lose weight, and those who claimed they haven’t

Ozempic for weight loss: While some international celebrities have openly discussed taking the drug, including some of its negative effects, others have categorically denied using it (Images: Instgram)

Ozempic, the prescription drug that replicates the effects of GLP-1, a naturally occurring hormone in the body used to treat type 2 diabetes, has been quite the buzzword in 2025 for more reasons than one. Known to trigger weight loss by causing a feeling of fullness and reducing hunger cravings, its increased global usage has sparked widespread interest, with many people speculating about drastic celebrity weight loss associated with the drug.

While some international celebrities have openly discussed taking the drug, including some of its negative effects, others have categorically denied using it. Either way, they haven’t shied away from sharing their views on the drug. Here’s what they’ve said publicly.

Karan Johar

Karan Johar credited OMAD (One Meal a Day) for his weight loss along with weight training and paddle

Karan Johar, who in recent years has shed a massive amount of weight, has been accused of using the drug for his drastic transformation. However, in his tell-all interview with Raj Shamani, he denied it. “Now people ask me, ‘Are you on Mounjaro? Are you on Ozempic?’ I’m tired of these comments. People don’t know my truth.” Instead, he credited OMAD (One Meal a Day) for his weight loss along with weight training and paddle.

Serena Williams

Serena Williams: “GLP-1 helped me enhance everything that I was already doing — eating healthy and working out, whether it was as a professional athlete at the top level of tennis or just going to the gym every day'

Serena Williams spoke to People magazine about her struggle with weight loss and how GLP-1 helped her shed 31 pounds. “GLP-1 helped me enhance everything that I was already doing — eating healthy and working out, whether it was as a professional athlete at the top level of tennis or just going to the gym every day. So I think that it’s important for everyone to hear my story. And I feel like there's a lot of people that can relate,” she said.

Ram Kapoor

Ram Kapoor revealed that he lost 55 kgs in 18 months naturally, without the help of pills or surgery.

Ram Kapoor revealed losing 55 kgs in 18 months naturally, without the help of pills or surgery. However, people didn’t stop speculating, crediting the big change to the use of weight-loss drugs.

In an interview with Humans of Bombay in July 2025, the actor said, “It’s madness, ‘Ozempic liya hai.’ Toh kya hua? Ek zindagi jeeni hai, jo bhi shortcut doctor bol raha hai, lo! (You have taken Ozempic, so? What happened? You have one life, whatever shortcut the doctor gives, take it!)” said the Bade Achhe Lagte Hain actor.

He also reacted to the trolling and judgments passed on by many in the industry, adding, “Karan Johar, me, all of us who go through this Ozempic nonsense, you know why we don’t react? It’s because we know all these people know it; they are mad.”

Chrissy Teigen

Chrissy turned to the weight loss drug in 2020 after she miscarried

Chrissy turned to the weight loss drug in 2020 after she miscarried. It was her response to her “deep depression of seeing this pregnant belly with no baby in it,” she said on her podcast Self-Conscious. She added that she felt stuck after losing the baby at 20 weeks and gaining an extra 40 pounds. Her struggle with reduced hunger cues due to the medication was also a problem. “It was frustrating for me because I know that logically you need food to have energy,” she added.

Meghan Trainor

Meghan Trainor: “I’ve worked with a dietician, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy" (Images: @meghantrainor/Instagram)

After winning the 2025 Billboard Women in Music awards, Meghan expressed her disappointment with the comments directed at her body rather than her big achievement. She took to Instagram to express how disheartened she was, and said, “I’ve worked with a dietician, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great.”

Tamannaah Bhatia

Tamannaah Bhatia confessed to struggling with weight during Covid and shared how a woman’s body keeps changing every five years

This year, the actress wasn’t spared as she looked leaner than ever in her appearance, making fans speculate she had taken the weight-loss drug. However, Tamannaah clarified in an interview with Harper’s Bazaar India that she has always been slender and grown up in front of the camera, so there’s nothing to hide. She did confess to struggling with weight during Covid and shared how a woman’s body keeps changing every five years.

Elon Musk

Elon Musk openly admitted to using Mounjaro for weight loss on X, sharing his photo wearing a Santa Claus suit and flowing white beard sans the traditionally plump look

Last Christmas, Elon Musk openly admitted to using Mounjaro for weight loss on X, sharing his photo wearing a Santa Claus suit and flowing white beard sans the traditionally plump look. He humorously called himself “Ozempic Santa,” though admitted in comments that he uses Mounjaro, “but that doesn’t have the same ring to it.”

Disclaimer: This article, including health and fitness advice, only provides generic information. Don’t treat it as a substitute for qualified medical opinion. Always consult a specialist for specific health diagnosis.