Iran-Israel War: Tehran fires hypersonic missiles, Tel Aviv hits 'internal security' HQ; Khamenei warns US | Top updates

Israel and Iran exchanged fire again on Wednesday, the sixth day of strikes in their most intense confrontation in history, fuelling fears of a drawn-out conflict that could engulf the Middle East.

Here are the latest developments:

Iran launched several hypersonic missiles in a fresh attack. The Fattah hypersonic missiles "have successfully penetrated the Israeli regime's defenses," state TV reported. Meanwhile, Israel's army said it had detected new missiles launched from Iran, adding that its defensive systems were operating to intercept the threat.

The announcement came after Iran issued an evacuation warning for residents of the Israeli city of Haifa.

The US ambassador to Israel, Mike Huckabee, meanwhile announced plans for evacuating Americans by air and sea.

Iran was in a "near-total national internet blackout", London-based watchdog NetBlocks wrote on X.

Iran announced last week that it was placing temporary restrictions on the internet for the duration of the conflict, placing heavier limits on Wednesday.

The communication ministry said in a in a statement carried by Fars news agency that the limits were imposed due to Israel's "abuse of the country's communication network for military purposes."

Numerous sites and apps have been at least partially inaccessible.

State television appealed to Iranians on Tuesday to delete WhatsApp from their phones, charging that the messaging app gathers users' location and personal data and "communicates them to the Zionist enemy".

A WhatsApp spokesperson hit back against the claims, saying: "We're concerned these false reports will be an excuse for our services to be blocked at a time when people need them the most."

President Donald Trump said Wednesday he was considering whether the United States will join Israeli strikes on Iran and said that Tehran had reached out to seek negotiations on ending the conflict.

"I may do it, I may not do it. I mean, nobody knows what I'm going to do," Trump told reporters. "I can tell you this, that Iran's got a lot of trouble, and they want to negotiate."

Trump said Iran had even suggested sending officials to the White House for talks on Tehran's nuclear program in a bid to end Israel's air assault, but added that it was "very late".

When asked if it was too late for negotiations, he said: "Nothing is too late."

Israeli Defence Minister Israel Katz said air force jets had destroyed Iran's "internal security headquarters", while AFP journalists reported hearing blasts in Tehran.

"Air Force jets have just destroyed the internal security headquarters of the Iranian regime -- the main arm of repression of the Iranian dictator," Katz said in a statement, vowing to "strike symbols of governance and hit the Ayatollah regime wherever it may be".

Supreme leader Ayatollah Ali Khamenei said his nation would "never surrender", while warning the United States it would suffer "irreparable damage" if it intervenes in the conflict.

"This nation will never surrender," Khamenei said in a speech read on state television. "America should know that any military intervention will undoubtedly result in irreparable damage."

Trump had stepped up his rhetoric, saying on Tuesday that the United States knows where Khamenei is located but will not kill him "for now".

Israel's attacks have hit nuclear and military facilities around Iran, as well as residential areas.

Residential areas in Israel have also been hit, and foreign governments have scrambled to evacuate their citizens from both countries.

Israeli Prime Minister Benjamin Netanyahu's office said on Monday that at least 24 people have been killed in Israel and hundreds wounded since Iran's retaliatory strikes began Friday.

Iran said on Sunday that Israeli strikes had killed at least 224 people, including military commanders, nuclear scientists and civilians.