For the first time in history all four finalists in both the Champions League and Europa League come from the same country.
The 46-year-old Norwegian has guided United to 14 wins in 19 matches in all competitions as caretaker boss since replacing the sacked Jose Mourinho
A top-four finish will be seen as a remarkable achievement for both managers.
Tottenham will want to avoid defeat at all costs which will suck them into a busy race for a top-four finish with Arsenal, Chelsea and Manchester United breathing down their neck.
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Guardiola will be aware that a defeat at this stage of the season could be harder to recover from as they challenge for silverware on four fronts.
A win for City will once again open up the title race.
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Both teams will aim to strengthen their bid to finish in the top-4 when they lock horns at the Emirates Stadium.
The 36-year-old joined Arsenal from Chelsea in 2015, where he had spent 11 years.
He still holds the Premier League record for most clean sheets in a season (24) and went 1,024 minutes without conceding in 2004-05.
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Tottenham Hotspur and Manchester United lock horns in a thrilling encounter
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The defending champions Manchester City entertain Liverpool in a high-stakes contest at the Etihad Stadium, the outcome of which could have a bearing on who lifts the league title come May.
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Solskjaer, who leaves his role as manager of Norwegian club Molde, will be joined by Mike Phelan as assistant manager.
United have made their worst start to a league season in 28 years and were beaten 3-1 by arch-rivals Liverpoool on December 17 in what was Mourinho's final match in charge of the club.
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