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Vitamin D and colon cancer: 5 ways the Sunshine Vitamin lowers colon carcinoma risk

Vitamin D, also known as the sunshine vitamin, has been known for some time to do more than just benefit bone health. Studies have suggested that it can be highly effective in preventing colon cancer by regulating cell proliferation, enhancing immune function, and inhibiting inflammation.

August 22, 2025 / 12:52 IST
Vitamin D health benefits: Vitamin D helps prevent malignant cell development in the colon by suppressing the growth of cells, enhancing immune responsiveness, and decreasing the inflammatory response (Image: Canva)

Vitamin D, also known as sunshine vitamin, is more than your bone's best friend. Latest research suggests that Vitamin D can lower the risk of colon carcinoma — the world's second largest killer from cancer.

Vitamin D helps prevent malignant cell development in the colon by suppressing the growth of cells, enhancing immune responsiveness, and decreasing the inflammatory response.

Benefits of Vitamin D against colon cancer

The best way to avoid colon cancer is through prevention. When delivered through supplements, Vitamin D acts on the cellular level to turn off growth pathways and inflammation from the colon lining, says Dr Ananya Mehta, Oncologist and Nutrition Researcher at Global Health Institute. Vitamin D helps the body detect and eliminate precancerous cells at an earlier stage, the expert suggests.

Also read | 6 symptoms of colon cancer: Watch out for sudden weight, fatigue, blood in stoolRegulates cell growth and repair

Vitamin D attaches to specialised receptors in colon cells, which in turn affect the genes that control cell division and repair. Thus, it prevents excessive reproductive activity of the cells, which is a manifestation of cancer.

Promotes apoptosis (Programmed cell death)

One of the most common properties of tumor cells is their intrinsic ability to resist cell death mechanisms. Vitamin D promotes the apoptosis of abnormal cells, preventing the formation of potential tumors before they have the chance to form.

Reduces inflammation in the colon

There is a known link between chronic inflammation and colon cancer. Vitamin D can also reduce inflammation, which provides a better microbiome environment that is not so conducive to cancer changes.

Also read | Prevent colorectal cancer: 8 foods to avoid in your daily diet to reduce riskStrengthens immune surveillance

A strong immune system is a key player in identification and removal of abnormal cells. Vitamin D increases immune response, so the body can identify and eliminate precancerous cells sooner.

Improves gut microbiome health

Recent studies indicate that Vitamin D helps to keep a balanced gut microbiome, which in turn seems to help maintain a healthy intestinal wall, further preventing colon cancer.

Sources and optimal levels

Sunlight exposure is the main source from which the body makes Vitamin D in the skin. Deficiencies can occur if you are staying too much indoor, sunscreen use and the seasons. Food sources that can give adequate Vitamin D are fatty fish (salmon, tuna, mackerel), fortified dairy products, and eggs.

Disclaimer: This article, including health and fitness advice, only provides generic information. Don’t treat it as a substitute for qualified medical opinion. Always consult a specialist for specific health diagnosis.
Nivedita is a Delhi-based journalist who writes on health, fashion, lifestyle and entertainment. Views expressed are personal.
first published: Aug 22, 2025 12:52 pm

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