Prime Minister Benjamin Netanyahu on Thursday claimed that Israel was "changing the face of the world" in its war with Iran, now in its seventh day.
"I said that we're changing the face of the Middle East, and now I say we're changing the face of the world," he told public broadcaster Kan, adding that Israel had destroyed "more than half" of Iran's missile launchers.
Netanyahu said he welcomed "all help" with destroying Iran's nuclear sites, nearly a week into major Israeli air raids on the Islamic republic.
Israel is "capable of striking all of Iran's nuclear facilities" but "all help is welcome", Netanyahu told public broadcaster Kan, also saying that US President Donald Trump "will do what is good for for the United States, and I will do what is good for the State of Israel".
Earlier in the day, Israel's defence minister warned that Iran's supreme leader "can no longer be allowed to exist" after a hospital was hit in an Iranian missile strike.
As President Donald Trump dangled the prospect of US involvement, Soroka Hospital in the southern city of Beersheba was left in flames by a bombardment that Iran said targeted a military and intelligence base.
Meanwhile Russia, an Iranian ally, told the United States that joining the conflict would be an "extremely dangerous step".
Israel, fearing Iran is on the verge of developing a nuclear weapon, launched air strikes against its arch-enemy last week, triggering deadly exchanges.
Prime Minister Benjamin Netanyahu said Iran would "pay a heavy price" for the hospital strike, while Defence Minister Israel Katz issued a stark warning for supreme leader Ayatollah Ali Khamenei.
"Khamenei openly declares that he wants Israel destroyed -- he personally gives the order to fire on hospitals," Katz told reporters.
"He considers the destruction of the state of Israel to be a goal. Such a man can no longer be allowed to exist."
The latest escalation came on the seventh day of deadly exchanges between the two countries that have plunged the region into a new crisis, 20 months into the Gaza war.
Hospital director Shlomi Codish said 40 people were injured at the Soroka, where an evacuated surgical building was hit leaving smoke billowing.
"Several wards were completely demolished and there is extensive damage across the entire hospital," he told journalists at the site.
World Health Organization director-general Tedros Adhanom Ghebreyesus called attacks on health facilities "appalling", while UN rights chief Volker Turk said civilians were being treated as "collateral damage".
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