HomeNewsIndiaCOVID-19 vaccine update: 4 candidates in human trial stage, says Centre
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COVID-19 vaccine update: 4 candidates in human trial stage, says Centre

Jitendra Singh said Cadila Healthcare Ltd's DNA-based vaccine candidate is in phase three clinical trial and it has submitted the interim data for emergency use authorisation.

July 21, 2021 / 08:26 IST
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Currently, three vaccines -- Serum Institute of India's Covishield, Bharat Biotech's Covaxin and Russian vaccine Sputnik V -- are being administered in India.
Currently, three vaccines -- Serum Institute of India's Covishield, Bharat Biotech's Covaxin and Russian vaccine Sputnik V -- are being administered in India.

Giving updates on five potential COVID-19 vaccines, Science and Technology Minister Jitendra Singh on July 20 said that four candidates are currently in different stages of human trials. He said that another one, developed by Genique Life Sciences, is in the advanced pre-clinical stage.

In a written response to a question in the Rajya Sabha, Singh said Cadila Healthcare Ltd.'s DNA-based vaccine candidate is in phase three clinical trial and it has submitted the interim data for emergency use authorisation.

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While Biological E Ltd.'s vaccine candidate and Bharat Biotech International Ltd.'s adeno intranasal vaccine candidate are in phase three clinical trials, Gennova Biopharmaceuticals Ltd.'s mRNA-vaccine candidate is in phase one clinical trial, Singh said.

COVID-19 Vaccine
Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.
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