US President Donald Trump has stirred fresh debate after claiming that Tylenol (acetaminophen) use during pregnancy could increase the risk of autism in children. Speaking at a White House press briefing, Trump urged expectant mothers to “limit Tylenol use unless medically necessary,” warning, “Taking Tylenol is not good. I’ll say it. Not good.” He also suggested that the US Food and Drug Administration (FDA) is preparing to alert doctors about potential links to autism and ADHD.
What Does FDA Say?
Responding to the US President's claims, the FDA confirmed on September 22, 2025, that it is moving to update warning labels on acetaminophen products, citing evidence of a possible association between prenatal use and neurodevelopmental outcomes such as autism spectrum disorder (ASD) and ADHD. The agency has also issued a letter to physicians highlighting the growing body of research.
However, the FDA emphasised that this evidence remains associative, not causal. Large studies like the Nurses’ Health Study II and the Boston Birth Cohort have reported correlations, but no clear proof exists that acetaminophen directly causes autism. Importantly, the agency noted that acetaminophen continues to be the safest over-the-counter option for fever in pregnancy, since alternatives like aspirin and ibuprofen carry well-documented risks for the foetus.
What Does Research Say?
According to observational studies reviewed by the Yale School of Public Health, children whose mothers took paracetamol during pregnancy may be at slightly higher risk of developing ASD or ADHD. However, experts warn that these studies have drawbacks, such as recall bias, differences in timing and dosage, and the impact of additional environmental or health factors.
The American College of Obstetricians and Gynaecologists (ACOG) has reaffirmed that acetaminophen remains safe in pregnancy when used appropriately. The group stressed that untreated high fever or severe pain can endanger both mother and baby, and that short-term, guided use of acetaminophen is still recommended.
What Should Expectant Mothers Do?
Doctors advise women not to panic or abruptly stop taking acetaminophen if prescribed. Instead:
Also Read: Age, medications and other risk factors during pregnancy that increase autism chances
- Use the lowest effective dose for the shortest period.
- Avoid chronic or prolonged use without medical supervision.
- Explore non-drug remedies like rest, hydration, or cooling measures for mild symptoms. Consult a doctor before making any changes to medication.
Trump’s remarks have amplified anxieties, but health authorities urge perspective: the science is still unsettled. While the FDA is revising labels in the spirit of caution, experts emphasise that acetaminophen, when used responsibly, remains one of the safest choices during pregnancy.
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