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Covid spike to stabilise in two weeks, need to assess vaccine efficacy, develop new shots: Dr Guleria

The former AIIMS director said the coronavirus would continue to mutate and become more infectious, and that the country will continue to see smaller waves in the coming months.

April 14, 2023 / 18:57 IST
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As the active load of coronavirus cases in the country grew to an eight-month high, noted pulmonologist Dr Randeep Guleria, on April 14, highlighted the need to assess the efficacy of Covid vaccines against new variants. He added that the focus should be on developing new jabs to tackle emerging mutations.

“We should collect data to see the efficacy of the current vaccines against new variants. We should also develop new vaccines, which should be able to cover the emerging and new variants so that we have good vaccines available if there’s a sudden surge in cases,” Dr Guleria, former director of AIIMS, Delhi, told Moneycontrol.

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He said the strategies to deal with coronavirus should evolve with time.

“We already have a bivalent vaccine, Europe and the US are using it. India should also start looking at what should be done to stay ahead of the curve in terms of being able to develop a vaccine that deals with new variants or possible emerging variants,” he added.

COVID-19 Vaccine
Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.
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