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Early-onset Alzheimer's: Here's how stress, pollution, high sugar diet contribute to poor brain health

Alzheimer's disease: While genetics play a role in early-onset Alzheimer's, environmental and lifestyle factors are also emerging as significant contributors. Understanding these underlying causes is crucial for both prevention and treatment, especially as the global population faces increasing concerns about premature brain ageing.

September 20, 2024 / 14:37 IST
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One of the primary contributors to early-onset Alzheimer's disease is genetics. (Image: Canva)

Alzheimer's disease, traditionally associated with the elderly, is increasingly being diagnosed in younger adults. Known as early-onset Alzheimer's, this condition affects people who are in their 40s and 50s, much earlier than the usual age of onset in those over 65. This growing trend is concerning, as it signals a shift in how the disease develops and affects different populations. Dr Kapil Agarwal, Senior Consultant and Head of the Department of Neurology at Marengo Asia Hospital, Gurugram, emphasises that this trend is not just a result of genetic predisposition but also involves environmental and lifestyle influences. By addressing these factors early, it may be possible to mitigate the growing impact of this debilitating disease on younger generations.

Genetic factors and the role of the APOE gene

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One of the primary contributors to early-onset Alzheimer's disease is genetics. Research has identified the APOE (Apolipoprotein E) gene as a significant risk factor for Alzheimer's, especially in younger adults. Dr Agarwal explains that when the APOE gene is defective, it can accelerate brain degeneration, causing premature neuronal cell death.

However, genetics alone cannot account for the increasing number of early-onset Alzheimer's cases. Other factors, particularly environmental and lifestyle influences, play a critical role in the early development of the disease.