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Cardiologist explains who is more at risk of heart attack: Men or women?

Heart attack risk factors: Cardiovascular disease plays out differently in men and women. Even when diabetes and other risks affect them equally, gender differences mould the end results. Understanding these differences will help in personalised prevention and treatment options.

September 24, 2025 / 11:31 IST
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Symptoms of heart attack in women: Compared to men, women generally experience more subtle or different symptoms such as fatigue, shortness of breath, and nausea (Image: Pexels)

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. While traditional cardiovascular risk factors such as diabetes, hypertension, hypercholesterolemia, obesity, smoking, and lack of physical activity are common to both men and women, recent data reveals that the distribution of cardiovascular risk differs between genders.

Historically, myocardial infarction was predominantly associated with men, leading to little or no understanding of its impact on women. Research now highlights significant disparities not only in the levels of risk faced by men and women, but also in how symptoms manifest, treatment responses, and recovery processes differ between the sexes.

For instance, women may experience more subtle or different symptoms such as fatigue, shortness of breath, and nausea, which can be easily overlooked or misdiagnosed, delaying appropriate intervention. Conversely, men often exhibit the classic "elephant on my chest" pain associated with heart attacks, making recognition easier. Biological differences, hormonal influences, and lifestyle patterns also contribute to the variance in risk and outcomes.

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Also read | Cardiologists flag outdated symptoms of heart attack and stroke, say even the ‘healthy’ are at risk

Talking to Moneycontrol, Dr A Ramachandran, MD.Ph.D., D.Sc., FRCP(Lond)., MNAMS., FICP. FRCP (Edin), Chairman/Managing Director at Dr.A.Ramachandran’s Diabetes Hospitals, stresses the importance of understanding these differences for developing personalised prevention, diagnostic, and therapeutic strategies.