10 Ways To Manage And Treat Stubborn Warts Effectively

By Rajeshwaari Kalla | August 22, 2025 | Image: Canva

What’s a wart?

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A wart is a small, rough skin growth caused by certain strains of the human papillomavirus (HPV). Though generally harmless, warts can spread & often recur

Start with observation

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About two-thirds of warts disappear within 2 years without treatment. Sometimes the best approach is to wait

Use salicylic acid

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This over-the-counter topical remedy softens the skin and dissolves the wart. It’s affordable and often effective

Try cryotherapy treatment

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Freezing the wart with liquid nitrogen may destroy the virus-infected tissue. It usually needs multiple sessions

Consider retinoic acid

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A vitamin A derivative that interrupts skin cell growth. It’s used especially for flat or stubborn warts

Apply 5-fluorouracil carefully

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Traditionally for sun-damaged skin, this topical cream may clear warts when used under bandages for 30 days

Use podophyllin cautiously

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An anti-mitotic agent applied by doctors. It helps stop wart cells from growing but needs expert handling

Explore immunotherapy options

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Injections like Candida antigen or interferon stimulate the immune system to fight off persistent wart infections

Consider systemic treatments

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Oral medications like cimetidine or retinoids have been used in severe or widespread wart cases

Look into alternative therapies

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Though lacking strong evidence, some try hypnosis, propolis, or herbal remedies—worth a try if warts persist

Last resort: Surgery

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For recurrent or large warts,  options include laser removal,  excision, or electrodesiccation. 

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