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Coronavirus | Germans clamour for COVID-19 vaccines, but shun AstraZeneca’s offering

Many people — including health workers — are skipping appointments or refusing to sign up for the AstraZeneca shot, which they fear is less effective than the Pfizer-BioNTech vaccine

February 26, 2021 / 02:57 PM IST
(Image Source: Shutterstock)

(Image Source: Shutterstock)

Melissa Eddy

BERLIN — At the start of the year, many Germans were complaining about a shortage of coronavirus vaccines that could free them from onerous lockdowns and limited social lives. Just weeks later, many are now upset that they’re not getting the vaccine they want.

As people around the world clamour for inoculations, and many countries have seen severe shortages, a preference for a vaccine developed by the German company BioNTech with Pfizer, is causing a pileup in Germany of the shot developed by AstraZeneca, a British-Swedish company, according to state health officials.

Many people — including health workers — are skipping appointments or refusing to sign up for the AstraZeneca shot, which they fear is less effective than the Pfizer-BioNTech vaccine, the officials said. As a result, two weeks after the first delivery of 1.45 million doses of the AstraZeneca vaccine arrived in Germany, only 270,986 have been administered, according to data collected by the public health authority, the Robert Koch Institute.

“The point is that we have a German-made product that is the market leader, but we are not able to get it,” said Michael Breiden, 53, a night nurse in a psychiatric hospital in the western state of North Rhine-Westphalia. He said he would prefer the Pfizer-BioNTech shot, but would take the AstraZeneca one if it meant getting immunized more quickly.


COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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The rejection of the AstraZeneca vaccine has been fuelled by weeks of negative coverage about it in the German media, which has portrayed it as “second-class,” citing its lower efficacy rate compared with Pfizer-BioNTech, and reporting stories of people suffering adverse reactions.

Clinical trials do suggest that Pfizer’s efficacy, at 95%, is higher than AstraZeneca’s, which is between 60% and 90% depending on factors such as the spacing of doses. Still, it is difficult to directly compare shots unless they are tested head-to-head in the same trial. And many health professionals suggest getting whichever vaccine is available first since COVID poses such health risks.

All the leading vaccines offer strong protection against severe disease and death, but as the overall efficacy rates show, some appear to do better than others in protecting against any form of the disease. Even mild or moderate COVID cases can lead to long struggles with symptoms.

Widespread scepticism about vaccines in Germany has exacerbated people’s reluctance to take the AstraZeneca shot. Medical and other front-line workers also have expressed resentment about being given unused AstraZeneca shots, instead of the Pfizer-BioNTech one, saying it showed a lack of respect after their efforts to help the country fight the pandemic over the past year.

The rejection of the AstraZeneca vaccine has caused delays in a mass vaccination campaign that was already struggling with bureaucratic and logistical hurdles. That has raised concerns that, with new cases of coronavirus infection increasing, even as Germany remains largely locked down, failure to immunize enough people quickly enough could stymie efforts to return the country to normal life.

“Vaccinating fast is the order of the day,” Germany’s president, Frank-Walter Steinmeier, told citizens in Bavaria during a videoconference Thursday, stressing that all three vaccines in use in Germany had been approved by the European Medicines Agency and were trustworthy.

“I personally have little sympathy for the reluctance to use one vaccine or another,” he said. “This is a first-world problem, certainly for those who are still waiting for their first vaccination and even more so for people in countries who might not even have the prospect of receiving a first inoculation this year.”

Check here for the latest updates on all COVID-19 vaccines

President Emmanuel Macron of France, who had previously dismissed the AstraZeneca vaccine as questionably effective for older age groups, told reporters Thursday that he would take it himself, responding to reports of the shot facing scepticism in several parts of Europe.

The problem runs deeper than just AstraZeneca. According to a survey by the Bertelsmann Foundation, one-third of Germans say they would not get vaccinated, regardless of who made the shot. In addition to AstraZeneca, Germany is also administering the vaccine made by Moderna, an American company, without problems or resistance. The vaccine has an overall efficacy of 94.5%.

AstraZeneca’s vaccine has been generating negative headlines in Germany since January, when the company said it would significantly cut planned deliveries to the European Union. Days before the first doses were delivered, Germany’s vaccine commission recommended that the AstraZeneca shot be given only to adults up to age 65, citing a lack of sufficient data on its efficacy in older people, advice that was followed by Chancellor Angela Merkel’s government.

Then several hospitals were forced to temporarily stop administering AstraZeneca shots after a number of people called in sick the day after their inoculations after experiencing what are considered normal reactions to the vaccine. Although the hospitals have since resumed vaccinations at a slower rate, the headlines created further uncertainty.

The World Health Organization has recommended the AstraZeneca vaccine for countries where variants are circulating, and Germany’s leading virus experts, the health minister and Merkel, have all defended it as safe. Recent data from use of the vaccine in Scotland showed that even after one dose, the AstraZeneca vaccine could reduce the risk of hospital admissions by roughly 94%.

But the numbers that have stuck in the minds of many people are those from earlier trials showing that AstraZeneca provides 70% efficacy in protecting against COVID-19, and that the one developed by BioNTech and Pfizer showed higher efficacy.

Dr. Lisa Koch, a dentist from Berlin, said she was surprised at the number of young workers in her office who said they would not get vaccinated, although their jobs meant spending several hours a day around unmasked patients. Only the three dentists and another staff member agreed to be immunized, she said.

“They think that the vaccine is not safe, that it won’t work, or could even harm them,” she said, adding that most of those rejecting the jabs were in their 20s or 30s. “They are all a bit younger, maybe they have the feeling that they don’t need it.”

Ursula von der Leyen, the president of the European Commission, who is also a medical doctor, said that several months ago, before the vaccines had been through their final clinical tests, the hope was that they could reach at least 50% to 70% efficacy.

“I would not hesitate to get vaccinated with AstraZeneca any more than I would with other vaccines from BioNTech-Pfizer or Moderna,” von der Leyen told the Augsburger Allgemeine newspaper.

German doctor associations have issued an appeal urging all medical staff to take advantage of the opportunity to get a shot, stressing that all vaccines approved by the authorities were safe and provided more protection than not getting vaccinated at all.

A study of Britain’s mass inoculation program, released this week, pointed to the effectiveness of the vaccine, even among older people. The study also showed that from 28 to 34 days after the first shot, when it appeared to be at or near peak effectiveness, the AstraZeneca vaccine reduced the risk of COVID-19 hospital admissions by roughly 94%.

But all that has not convinced many in Germany.

Berlin police officers have been unsuccessfully asking state health authorities to make vaccines available for them, said Benjamin Jendro, spokesperson for the police union in Berlin.

But this week, with thousands of unused doses of AstraZeneca available, the union was told that 24,000 would be earmarked for the force. “Now all of the sudden, because no one else wants the AstraZeneca, they say we can have it,” he said. “It is all still very new, but when others reject something and then it is offered to the police, it is understandable that many colleagues feel burned. And they are worried, there are so many conflicting reports.”

“Some of the colleagues say they will take it immediately, others are more uncertain,” he said.

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