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UK, India COVID-19 study awarded Guinness world record

Funded by the UK government’s National Institute of Health Research (NIHR), the researchers concluded that patients waiting for elective surgery should be treated as a vulnerable group and access COVID-19 vaccines ahead of the general population – potentially helping to avoid thousands of post-operative deaths linked to the virus.

August 26, 2021 / 07:57 PM IST

A worldwide COVID-19 study led by UK experts and conducted at Indian hospitals among others around the world has been awarded the ‘Guinness World Records’ title for the world’s largest scientific collaboration, involving over 140,000 patients in 116 countries.

The record for ‘Most authors on a single peer-reviewed academic paper’ is now held by the Universities of Birmingham and Edinburgh after 15,025 scientists around the globe contributed to the major research into the impact of COVID-19 on surgical patients.

The co-lead author of the study, Indian-origin surgeon Aneel Bhangu from the University of Birmingham, said the study was aimed at improving our understanding of the deadly virus.

“Being awarded the ‘Guinness World Records’ title for the world’s largest scientific collaboration highlights the scale of our global partnership, which aims to contribute to our understanding of COVID-19 and help to save as many lives as possible around the world,” said Dr Bhangu.

“It marks the commitment and hard work of thousands of medical colleagues around the world to understand the changes that are needed in how surgery must be delivered if we are to beat the virus and reduce its impact on surgical patients,” he said.

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COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Funded by the UK government’s National Institute of Health Research (NIHR), the researchers concluded that patients waiting for elective surgery should be treated as a vulnerable group and access COVID-19 vaccines ahead of the general population – potentially helping to avoid thousands of post-operative deaths linked to the virus.

This was seen as particularly important for low and middle income Countries (LMICs) where access to vaccination remains limited and mitigation measures such as nasal swab screening and COVID-free surgical pathways to reduce the risk of virus-related complications are not available for many patients.

Overall, the scientists estimated that global prioritisation of pre-operative vaccination for elective patients could prevent an additional 58,687 COVID-19-related deaths in one year.

The COVIDSurg Collaborative international team of researchers published its findings in the ‘British Journal of Surgery’ (BJS), Europe’s leading surgical journal, after studying data from 1,667 hospitals in countries including India, the UK, Australia, Brazil, China, the UAE and the US.

In India, the study was conducted across 56 hospitals – among the largest alongside Germany and Italy.

Co-author James Glasbey, a surgical trainee from the University of Birmingham, commented: “Over 15,000 surgeons and anaesthetists from across 116 countries came together to contribute to this study making it the largest ever scientific collaboration, surpassing even ground-breaking research from the Large Hadron Collider at CERN in Switzerland.

“Every day we hear in the news that waiting lists are growing, and patients are unable to access the surgery that they need. This situation sadly is deteriorating in countries all over the world. Policy makers can use the data from this scientific collaboration to safely restart elective surgery.”

Launched in March 2020, the COVIDSurg Collaborative has provided data needed to support changes to surgical delivery in the fastest time frame ever seen by a surgical research group, Birmingham University said.

Research from this huge study group has also explored the timing of surgery after COVID infection, preoperative isolation, and risks of blood clots, all published in the field-leading journal 'Anaesthesia'.

According to the experts, during the first wave of the pandemic, up to 70 per cent of elective surgeries were postponed, resulting in an estimated 28 million procedures being delayed or cancelled.

Whilst surgery volumes have started to recover in many countries, ongoing disruption is likely to continue throughout 2021, particularly in the event of countries experiencing further waves of COVID-19.

Vaccination is also likely to decrease post-operative pulmonary complications, reducing intensive care use and overall healthcare costs.

Follow our full coverage of the coronavirus pandemic here.
PTI
first published: Aug 26, 2021 07:51 pm
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