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Japan stops use of 1.63 million Moderna doses over contamination

Takeda, which is in charge of sales and distribution of the Moderna shot in Japan, said it had "received reports from several vaccination centres that foreign substances have been found inside unopened vials."

August 26, 2021 / 01:17 PM IST
Source: Reuters

Source: Reuters

Japan will halt the use of 1.63 million doses of Moderna's Covid vaccine after reports of contamination in several vials, drugmaker Takeda and the health ministry said on Thursday.

Takeda, which is in charge of sales and distribution of the Moderna shot in Japan, said it had "received reports from several vaccination centres that foreign substances have been found inside unopened vials."

"Upon consultation with the health ministry, we have decided to suspend the use of the vaccine" from three whole batches from Thursday, it added.

The firm said it had informed Moderna and "requested an urgent investigation." Moderna did not immediately respond to a request for comment.

Takeda did not detail the nature of the contamination, but said it had not so far received any reports of health concerns arising from affected doses.

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COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

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There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

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Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Contaminants were seen inside vials from one of the three batches, but officials suspended the use of vials from the two others as a precaution, said top government spokesman Katsunobu Kato.

"We have not received reports of health problems stemming from the foreign object," he told reporters.

"But we are asking people to consult their physicians if they experience any abnormality."

Japanese media said the three batches were all produced in Spain at the same time.

Contaminants were seen in 39 unopened vials at eight vaccination locations in central Japan, including Tokyo, according to national broadcaster NHK.

The defence ministry said doses from a suspended batch had been administered between August 6-20 at its mass vaccination centre in the western city of Osaka.

However, staff visually check vials for contaminants before injecting the formula, the ministry said, adding that its Tokyo vaccination centre was not affected.

Kato said there had been no "concrete reports" that doses confirmed to contain contaminants had been administered.

The health ministry said it would work with Takeda to secure alternative doses to avoid disruption to the country's vaccine programme, which has ramped up after a slow start.

Takeda Pharmaceutical declined to elaborate details, citing Moderna's investigation. But a company spokesman said the firm encouraged the public to seek vaccine shots.

Around 43 percent of Japan's population has been fully vaccinated, as the country battles a record surge of virus cases driven by the more contagious Delta variant.

Around 15,500 people have died from Covid-19 in the country during the pandemic, and large parts of Japan are under virus restrictions.

Follow our full coverage of the coronavirus pandemic here.
AFP
first published: Aug 26, 2021 01:17 pm
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