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AstraZeneca COVID vaccine has 'winning formula': Chief Executive

The vaccine, currently being evaluated by Britain's independent medicines regulator, provides "100 percent protection" against severe COVID disease requiring hospitalisation, Pascal Soriot said in an interview with the Sunday Times newspaper.

December 27, 2020 / 05:45 PM IST
Source: Reuters

Source: Reuters

The COVID-19 vaccine developed by the British drugs group AstraZeneca and the University of Oxford has achieved a "winning formula" for efficacy, the company's chief executive said on Sunday.

The vaccine, currently being evaluated by Britain's independent medicines regulator, provides "100 percent protection" against severe COVID disease requiring hospitalisation, Pascal Soriot said in an interview with the Sunday Times newspaper.

He added he believes trials will show his firm has achieved a vaccine efficacy equal to Pfizer-BioNTech at 95 percent and Moderna at 94.5 percent.

“We think we have figured out the winning formula and how to get efficacy that, after two doses, is up there with everybody else," the chief executive said, while saying only that data would be published at "some point".

The UK government announced on December 23 that the developers of the Oxford-AstraZeneca vaccine had submitted their data to the Medicines and Healthcare products Regulatory Agency (MHRA).

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COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Approval is expected to be granted Monday to roll out the jab, The Sunday Telegraph newspaper reported.

The Pfizer-BioNTech vaccine was the first coronavirus shot to be authorised for use by the UK's independent medicines regulator and has been given to 600,000 of the country's most vulnerable people since last month.

Earlier trials had shown varying outcomes in the AstraZeneca shot's efficacy. The vaccine intially showed an average 70 percent effectiveness but that level jumped to 90 percent depending on dosage.

'Storm' over data

Behind this average figure from large-scale trials in the UK and Brazil was a 62 percent effectiveness for those who were vaccinated with two full doses of the shot.

For volunteers who received a half-dose first and then a full dose one month later, however, the vaccine was found to have 90 percent efficacy.

Soriot said he was "surprised" by the initial findings. "We would have preferred a simpler set of results," he added.

The lack of clarity and transparency over the discrepancy in the results was widely criticised. Soriot said he had not expected the pushback that followed.

"We assumed people would be a bit disappointed, that’s for sure," he said. "But we didn’t expect that storm".

Great hopes have been placed in the AstraZeneca shot, originally based on a weakened version of a chimpanzee virus, because of its low cost.

AstraZeneca's vaccine also enjoys a logistical advantage over the Pfizer-BioNTech alternative, as it can be stored, transported and handled at normal refrigerated conditions of between two and eight degrees Celsius (36-46 Fahrenheit) for at least six months.

That is a far cry from the -70C needed for Pfizer/BioNTech's offering and could allow use of the existing refrigerated supply chain to cut costs.

'Light at the end of the tunnel'

In a vote of confidence for its homegrown vaccine, the bulk of Britain's requirements are expected to be met by the jab.

The government has ordered 100 million doses, with 40 million doses scheduled to be available by the end of March.

UK officials will hope that confidence is rewarded, not least because the country has been one of the countries most affected by the pandemic with more than 70,000 deaths.

A surge in cases has hit nationwide over the past week, falling especially on the southeast of England and blamed on a new strain of the virus believed to be more infectious, which was first identified in the UK.

According to one British study the strain is 50 percent to 74 percent more contagious.

In an effort to contain the spread of the disease, millions across Britain were placed under tougher lockdown restrictions that came into force on 26 December.

Dozens of countries have also imposed travel restrictions on the UK to stop the spread of the new strain.

Writing in the Mail on Sunday newspaper, Finance Minister Rishi Sunak acknowledged it had been "a tough year for everyone in this country".

However, he added that "the early roll-out of vaccines – and the incredible work of our scientists and NHS – means we can now see light at the end of the tunnel".

Nearly 200 million doses of the AstraZeneca vaccine will be made before the end of the year, the UK drug manufacturer has said, and more than 700 million globally by the end of March next year.

Follow our full coverage of the coronavirus pandemic here.
AFP
first published: Dec 27, 2020 05:45 pm

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