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Very large' number of Indians may be protected from Omicron: Eminent virologist Shahid Jameel

Shahid Jameel, who is the former head of the advisory group to the Indian SARS-COV-2 Genomics Consortia (INASACOG), said people must be cautious and keep wearing masks.

November 30, 2021 / 12:30 PM IST
Shahid Jameel, director of the Trivedi School of Biosciences, Ashoka University, declined to give a reason for his resignation. (Image: Wikimedia Commons)

Shahid Jameel, director of the Trivedi School of Biosciences, Ashoka University, declined to give a reason for his resignation. (Image: Wikimedia Commons)

A"very large" number of Indians are likely to remain protected from Omicron or any other variant of COVID-19 and there is no need to panic, eminent virologist Dr. Shahid Jameel has said.

Jameel, who is the former head of the advisory group to the Indian SARS-COV-2 Genomics Consortia (INASACOG), said people must be cautious and keep wearing masks.

''While we should be cautious, there is no need to panic. India's second wave due to the Delta variant was huge, infecting more people than we imagined. This is reflected in the fourth National Sero survey that showed 67 percent of Indians to have Covid antibodies. That is about 930-940 million people at a time when the vaccination levels were very low, and so it came mainly from infection,'' he told PTI in an interview.

''More recently, Delhi showed 97 percent with antibodies, Mumbai around 85-90 percent, and so on. All this means that a very large fraction of Indians will be protected from severe disease caused by Omicron or any other variant,'' Jameel said.

A new variant of COVID-19 feared to have a high amount of spike mutations, has been detected in South Africa. On November 26, the WHO had designated B.1.1.529 as a variant of concern and named it Omicron.

Speaking on the effectiveness of vaccines against the new variant, Jameel said more data is awaited but vaccine effectiveness against the variant may dip by a few points. However, vaccines will not become useless, he said.


COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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''We don't have this data available yet. It may take another one to two weeks for the first laboratory results to become available. My hunch is that vaccine effectiveness against this variant may dip a few points, but vaccines will not become useless. They will continue to protect from severe disease,'' he said.

On how India can prepare to tackle the new variant, he said people should not panic, and continue to wear masks while the government should increase the rate of vaccination.

''We are fortunate to have sufficient vaccines and the ability to vaccinate. Along this line, it may help to reduce the duration between two doses of Covishield from 16 weeks to 12 weeks. This will get more people vaccinated quickly, especially those in vulnerable age groups (elderly), those with comorbidities, and those in high-risk occupations (health care),'' he said.

On what role a booster dose of vaccine can play against the new variant to tackle waning immunity against COVID-19, he said booster shots help, but it is more important to first get more people vaccinated with two doses. ''Further, about 90 percent of doses in India are Covishield, and this has limited use as a booster. For that, we will need either RNA, DNA, or protein vaccines. For the moment, just make sure more and more people get the two doses,'' he said.

Responding to reports claiming that the variant mainly affects people below 25 years of age, he said there is no data available on the subject.

''So far, the few known patients are in this age group. I doubt it will pose a bigger threat to children who naturally have no or mild disease to this virus,'' Jameel said.
first published: Nov 30, 2021 12:34 pm
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