Upcoming Webinar:Join our experts for discussion on ‘Re-inventing Finance: with Process, People & Technology’.
you are here: HomeNewscoronavirus

Supply Isn’t the Only Thing Stymying Europe’s Vaccine Rollout

The temporary suspension last week by multiple countries of AstraZeneca, the vaccine that the European Union has bet on, was only one indication of how Europe’s rollouts have been plagued by an overabundance of caution, bad deals and flouted obligations by pharmaceutical companies that have created a supply shortage.

March 25, 2021 / 10:49 PM IST
A person walks along a row of closed shops in Milan on March 15, 2021. A nearly national lockdown went into effect in Italy on March 15. Bureaucratic inertia, a diffusion of responsibility and logistical problems have seriously undercut vaccination efforts in Europe. (PC-Alessandro Grassani/The New York Times)

A person walks along a row of closed shops in Milan on March 15, 2021. A nearly national lockdown went into effect in Italy on March 15. Bureaucratic inertia, a diffusion of responsibility and logistical problems have seriously undercut vaccination efforts in Europe. (PC-Alessandro Grassani/The New York Times)

The mayor of Cremona, one of the northern Italian towns first hammered by the coronavirus during the pandemic’s initial explosion in Europe, received a call over the weekend that the local vaccination center was empty. The region’s booking system had failed to set up appointments with older residents, leaving more than 500 doses of vaccine at risk of going to waste.

“There was staff, there were also vaccines, but there were no people,” said the mayor, Gianluca Galimberti, adding that the situation had been bad for weeks.

Similar scenarios are playing out throughout the country, as authorities struggle to get vaccines to older and vulnerable Italians who most need them.

AstraZeneca says COVID-19 vaccine 76% effective, slightly lower than data cited earlier

Europe’s vaccination efforts are moving at a maddeningly slow pace compared with those in United States and Britain. The temporary suspension last week by multiple countries of AstraZeneca, the vaccine that the European Union has bet on, was only one indication of how Europe’s rollouts have been plagued by an overabundance of caution, bad deals and flouted obligations by pharmaceutical companies that have created a supply shortage.

Close

COVID-19 Vaccine

Frequently Asked Questions

View more
How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

View more
Show

The situation remains dire enough that the European Union unveiled emergency restrictions Wednesday to curb exports of COVID-19 vaccines for six weeks. But that drastic step is unlikely to solve many of the problems that have plagued Europe’s vaccine rollouts.

Even when supply is not the issue, bureaucratic inertia, strategic errors, a diffusion of responsibility and logistical problems in booking appointments have seriously undercut vaccination efforts.

In Italy, those missteps have especially affected the older, and most vulnerable, population. A full year after the country became the first Western nation to confront the virus, it now has the dubious distinction of having the highest rate of daily deaths from COVID-19 among Europe’s major powers. About 1 in 5 people older than 80 have received both doses of a vaccine, and about 5% of septuagenarians have received their first shot.

When it comes to distributing vaccines, Italy is on par with France and Germany and a little behind Spain, but its difficulties in vaccinating older citizens have constituted a lethal failure in a country that has the oldest population in Europe.

Prime Minister Mario Draghi recognized the problem in a speech to the Italian Senate on Wednesday, saying that while the pace of vaccinations was beginning to increase, it was “crucial to first vaccinate our elderly and fragile citizens who have more to fear for the consequences of the virus.”

To speed things up, his new government has sought to centralize the response, putting a general in charge and mobilizing the military and an army of new vaccinators — a departure in a country where much authority has been given to regional leaders over time.

Such steps underscore Europe’s rising desperation in the midst of a brutal third wave.

Italy’s infection fatality rate reduced only slightly during the first two months of its vaccination campaign, forcing the government to try to protect its unvaccinated citizens with a nearly national lockdown that began March 15.

Italians, who have been through so much, are searching for reasons for their latest affliction.

In its initial rollout in late December, Italy gave the Pfizer vaccine to health care workers, giving it an early lead in Europe. But its plan was then to make large use of the cheaper and easier-to-store AstraZeneca vaccine, which has since been dogged by supply shortages and various concerns about its safety and efficacy.

Last week, Italy and other major European countries briefly suspended the vaccine’s use over worries that it possibly caused blood clots in a handful of cases. This week, U.S. regulators raised concerns that the company may have skewed data to make the vaccine look more effective than it is.

Even before the recent chaos, Italy’s version of the Food and Drug Administration recommended that the vaccine’s use be limited to “individuals between 18 and 55 years” because of questions about how well the vaccine worked for older people.

As a result, Italy moved early on to vaccinate teachers within the age range, but also lawyers, prosecutors and hospital administrative staff. Older people, vulnerable and frustrated, went unvaccinated, while Italy’s death rates remained high. On Tuesday, 551 people died of the virus, the most since January.

On Wednesday, Draghi said that differing approaches by the regions to vaccinating people over the age of 80 was unacceptable, adding that some “neglect their elderly to favor groups who claim priority based probably on some contractual power.”

In Tuscany, a region usually admired for its health care system, only about 6% of people over the age of 80 have been fully vaccinated, prompting a public letter from leading citizens.

“Inefficiency,” they wrote, “produces deaths.”

Matteo Villa, a researcher at the Italian Institute for International Political Studies who has studied the coronavirus pandemic, said that Italy’s strategy of first vaccinating only health care workers had resulted in a bottleneck that made the virus more deadly.

“When the delays came,” he said, “we still had a lot of elderly people to vaccinate.”

Guido Bertolaso, the former head of Italy’s civil protection agency who is now in charge of the vaccine campaign in Lombardy, said the country had failed to act on emergency footing.

He blamed pharmaceutical companies not making good on their promised deliveries for Italy’s problems.

“When you plan, you must know where you get the vaccine, at what time, which amount, on a weekly basis,” he said. In any case, he added, “In Italy with planning, we are not very good.”

(Authors: Jason Horowitz and Emma Bubola)/(c.2021 The New York Times Company)
New York Times

stay updated

Get Daily News on your Browser
Sections