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Hype or hope? Oxford COVID-19 vaccine trial data is expected today — what we know so far

The data will be published in British peer-reviewed medical journal the Lancet.

July 20, 2020 / 10:45 PM IST

The early-stage human trial data of the COVID-19 vaccine that has been developed in a joint collaboration between Oxford University and British-Swedish drugmaker AstraZeneca will be released on July 20.

The data, which has been widely anticipated, will be published in British peer-reviewed medical journal the Lancet. The Oxford vaccine, also known as ChAdOx1 nCoV-19, was developed by the Jenner Institute and Oxford Vaccine Group, at the University of Oxford.

The vaccine uses a weakened version of chimpanzee adenovirus as a vector, infused with the genetic material of SARS-CoV-2 spike protein. 

Adenovirus is a benign virus that causes the common cold, and so the safety of the vaccine is assured. The Chimpanzee adenovirus is used to help circumvent the problem of pre-existing immunity encountered with other human adenovirus vectors.

A vaccine not just protects a person from the disease, but it is considered to be the fastest and surest way to reach herd immunity, where a sufficient percentage of the population becomes immune to a disease. It makes the spread of the disease from person to person unlikely.


COVID-19 Vaccine

Frequently Asked Questions

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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What is the significance of the data?

The data related to early-stage trials helps us to gauge two things - safety and efficacy of the vaccine. The efficacy here means whether the vaccine protects people from COVID-19 infection. 

The officials who are part of Oxford vaccine said earlier this month that they were encouraged by the immune response they had seen in phase-1 trials. 

Media reports say that the vaccine given in two doses provides double protection which means it is capable of producing neutralising antibodies, and also spurs T-Cell, a type of white blood cells called to fight COVID-19. 

We may also get comparative data about the neutralising antibodies produced by the vaccine to antibody levels observed in recovered COVID-19 patients. If vaccine-induced antibodies are much higher, it theoretically proves that the vaccine is working. We still don't know how long these antibodies remain in the human body. The data today will help us to get some answers to these questions.

Why does Oxford vaccine generate a lot of interest?

University of Oxford has been working on vaccines on MERS (Middle East Respiratory Syndrome) and Severe Acute Respiratory Syndrome (SARS) diseases, which are caused by coronaviruses. 

So, it immediately jumped into the fray to develop a COVID-19 vaccine as soon as it saw the outbreak. This gave it a lead time over other vaccine makers. The potential vaccine is already in large-scale phase III human trials to assess whether it can protect against COVID-19. 

In phase-3, it will be tested on roughly 30,000 people in the US alone. AstraZeneca is also in the process of starting the trial in Brazil. As per media reports, David Carpenter, Chairman, Berkshire Research Ethics Committee, which had approved the Oxford vaccine trials hinted that the vaccine could be fairly widely available around September and that is the sort of target they are working on. Except for US biotech Moderna's mRNA vaccine, no other vaccine has come this far.

Relevance to India

In India, AstraZeneca's partner Serum Institute of India will also be initiating the clinical trials soon. Serum will be producing one billion doses for India and other low and middle-income countries. If everything goes as per the plan, the vaccine is supposed to be launched by the end of this year.

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Viswanath Pilla is a business journalist with 14 years of reporting experience. Based in Mumbai, Pilla covers pharma, healthcare and infrastructure sectors for Moneycontrol.
first published: Jul 20, 2020 02:59 pm
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