Portal Hypertension Explained: From Liver Damage to Brain Fog

By Rajeshwaari Kalla | July 23, 2025 | Images: Canva

Pressure in Portal Vein

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When the blood pressure in the portal vein, carrying blood from the intestines to the liver, increases more than 10 mm Hg, it is called portal hypertension

What Can Cause It

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It can increase due to liver cirrhosis, Wilson’s Disease, and non-alcoholic steatohepatitis (NASH). Inflammation of the heart muscle can also cause this

Other Conditions Behind It

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Other causes include inflammation of the liver (hepatitis) and congestive cardiac failure, as well as portal pyaemia (infection and thrombosis of portal vein)

The Yellow Sign

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You may observe yellowish discolouration of the skin and  the mucous membrane, which  refers to jaundice. Anaemia may  be present alongside

The Graveyard Organ Grows

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An enlarged spleen, the organ on the left side of the abdomen, which is also  called the graveyard of red blood cells,  is commonly seen

General Body Complaints

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Generalised symptoms like weakness, tiredness, and anorexia can be observed in people with portal hypertension, along with abdominal pain

When Varices Burst

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If the portal varices start to bleed, they can lead to blood in the vomit, blackish coloured stools, and features of  shock, which require immediate  medical attention

Brain Fog and More

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Portal hypertension can also affect brain functioning and cause loss of memory, altered mental status, and episodes  of unconsciousness

When Fluid Fills the Belly

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Fluid collection can also occur in such cases. Excess fluid in the abdominal cavity is called ascites, which is one of the classic findings in this condition

Tests and Treatment

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After necessary investigations like haemoglobin levels, liver function tests, CT scan and MRI, treatment of all the above symptoms is required

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