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Scientists have found that depriving tumour cells of a key protein halts their growth, a discovery that can lead to potential new anti-cancer therapy. When deprived of the protein, some cancer cells are unable to properly divide, a finding described by researchers from the University of Pittsburgh Cancer Institute (UPCI).
"This is the first time anyone has explained how altering this protein at a key stage in cell reproduction can stop cancer growth," said researcher Bennett Van Houten. "Our hope is that this discovery will spur the development of a new type of cancer drug that targets this process and could work synergistically with existing drugs," Houten said in a statement published in the Journal of Cell Science.
All cells have a network of mitochondria, which are tiny structures inside cells that are essential for energy production and metabolism. Dynamin-related protein 1 (Drp1) helps mitochondria undergo fission, a process by which they split themselves into two new mitochondria. In breast or lung cancer cells made to be deficient in Drp1, the researchers observed a huge network of highly fused mitochondria.
These cancer cells appear to have stalled during a stage in cell division called G2/M. Unable to divide into new cells, the cancer growth stops. Those cells that do try to divide literally tear their chromosomes apart, causing more stress for the cell. "Once we revealed this process for halting cancer cell growth by knocking out Drp1, we began looking into existing compounds that might utilise a similar mechanism.
"Now that we know affecting mitochondria in this manner inhibits cell growth, we could target drugs to this biological process to treat cancer," said Houten. The researchers found a compound called Mdivi-1 that makes cancer cells behave much the way they do when deficient in Drp-1. When used in combination with cisplatin, a drug already used to treat many solid cancers, rapid cell death can be induced in a wide range of cancer cells. This means that Mdivi-1 makes cisplatin work better.
Mdivi-1 is being tested in cancer cells in a laboratory setting. Those tests show that, while the compound acts as though it is depriving cancer cells of Drp1, it is actually using a different mechanism.
"To me, that's the serendipity of science, and it's really exciting. We were on the hunt for a drug that could make cancer cells deficient in Drp1 and, instead, we found a new cancer therapy that seems to work really well," said Houten.
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