Pradhan tweeted that he was resigning to go back to the startup world. He was a member of Infosys' executive council and was seen as one of the candidates for the CEO post once SD Shibulal retires in 2015.
Basab Pradhan, who was the global head of sales, marketing and alliances at Infosys, India's second largest software services exporter, has resigned.
"Leaving Infosys to go back to the startup world," Pradhan tweeted on Tuesday.
He was also a member of Infosys' executive council and was seen as one of the contender to succeed SD Shibulal as the CEO. Shibulal is due to retire in 2015.
Pradhan earlier had quit Infosys to start a technology startup called Gridstone Research in 2005. He rejoined the Bangalore-based firm two years ago when the company announced the new Infosys 3.0 strategy.
His resignation comes just three days before the company announces first quarter results and is the first high-profile resignation since the board reappointed NR Narayana Murthy as the executive chairman last month.